Tissue-scaffold biological interaction
Project title: Tissue-scaffold biological interaction
Recruiting and hosting institution: Università del Piemonte Orientale
Country: Italy
PhD enrollment: Università del Piemonte Orientale
Supervisors: Università del Piemonte Orientale (I): L. Rimondini, University of Salzsburg (AU), J. Dunlop.
Objectives: To study the effect of physical-chemical, morphological and micromechanical properties of the scaffolds on the cell functionality and tissue healing and regeneration
Expected Results: New knowledge about surface microtopography; materials, the morphology and micromechanical properties on cytofuctionality of bone cells, new knowledge on stem cells secretome in relation to topography-driven mechano-transduction. Protocols to optimize materials for clinical application.
Description: DC4 position is about investigating the following aspects
- to analyse in-vitro the links between physical-chemical, morphological and micromechanical material properties of the scaffolds including chemistry, surface morphology, and cells and tissues functionality including the formation of extracellular matrix , progenitors differentiation, macrophages polarization and interaction with the scaffolds;
- to optimize materials for specific cells and tissues responses and healing;
- to optimize materials for specific cells and tissues responses tissue healing under external physical stimulus;
- to produce data to feed and validate in-silico models.
The Doctoral Candidates will interact with other members of the project’s DCs in a multidisciplinary setting by taking part in training sessions and workshops. Each DC will also conduct secondments in order to broaden her/his scientific understanding of the project’s subject and develop soft skills.