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About the project

End-to-end multidisciplinary optimal design for improved personalized bioactive glass/ceramic bone substitute implants

ReBone aims at establishing a multidisciplinary PhD programme which will expand the current knowledge of the clinical use of bioactive ceramic implants for the treatment of bone defects. Its overarching scientific objective is thus to implement an end-to-end design workflow, through a platform of computational tools, that will assist clinical professionals in the development of personalised bone graft substitutes for the treatment of critical-size bone defects. Such an innovation will ensure that an optimal treatment solution is found on a patient-specific basis in terms of:

  • mechanical and mechano-biological performance;
  • surgical implantability,
  • and reliability of the manufacturing process.

To achieve its overarching aim ReBone will develop cutting-edge in-silico models based on advanced computational methods and advanced characterization and validation techniques for achieving personalized implants with the following characteristics:

  • tailored and reliable mechanical and physical properties;
  • best osteo-integration capability;
  • mechanical, physical and mechano-biological target functions with patient-specific constraints, that take into account the load-bearing anatomical location, the biomechanical stress and the quality of the tissue at the implantation sites, identified from selected clinical data.

Specific Objectives

  • To define a procedure for clinical image analyses to inform the personalized bone-substitute design, fully validating it on four selected clinical cases;
  • To pursue material formulations and related optimized printing processes based on Vat PhotoPolymerization (VPP) technology, characterised by high printing fidelity and minimal intrinsic material defects;
  • To validate computational personalized models for predicting the biomechanical response of bone replacement implants made of glass-ceramics (GCs) or glass-ceramic/hydroxyapatite (GC/HA) and glass-ceramic/zirconia (GC/zirconia) composites;
  • To validate algorithms for optimal design of implants with prescribed function and constraints;
  • To devise a mixed reality surgical planning for the four selected clinical cases.

Pillars

  • I – Development of high quality and reliable bioactive GC-based materials and related manufacturing technology – Material technology
  • II – Development of in-silico models for the prediction of the biomechanical properties of bone implants and of a multi-disciplinary optimization platform Bioengineering
  • III – Clinical perspective, mechano-biology and procedural planning in mixed reality space – Mechano-biology, clinics and mixed reality