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Methods for optimization of bone-substitute architectures

Project title: Methods for optimization of bone-substitute architectures
Recruiting and hosting institution: Politecnico di Milano
Country: Italy
PhD enrollment: Politecnico di Milano
Supervisors: Politecnico di Milano (I): P. Vena, Ludwig Boltzmann Institute (AU), B. Misof.
Objectives: To implement an optimization scheme for personalized bone-substitute implants.
Expected Results: Algorithms for implementing optimization methods integrating multidisciplinary objectives and constraints. Optimal design for the four clinical cases will be achieved.

Description: DC1 position is about investigating the following aspects

  1. Definition of design parameters (e.g. geometrical parameters) for the specific implant to be designed. Multi-disciplinary input will be managed in this task by defining quantitative parameters representing the implant response or constraints in the different areas (to mention a few: wall thickness, pore size, average/maximum curvatures or pore connectivity);
  2. Development of computational models able to determine the implant response in terms of biomechanics (stiffness and strength, fluid permeation and tissue growth) as functions of the design parameters;
  3. Development of algorithms for the identification of the optimal implants will be formulated by identifying the design parameters (selected within the design space) minimizing multi-disciplinary objective functions with prescribed constraints.

The Doctoral Candidates will interact with other members of the project’s DCs in a multidisciplinary setting by taking part in training sessions and workshops. Each DC will also conduct secondments in order to broaden her/his scientific understanding of the project’s subject and develop soft skills.

Required profile/research interests:

  • Master’s degree in Biomedical Engineering, Materials Engineering or related fields.
  • The degree must be completed with good grades, latest by the start of the recruitment.
  • Proficiency in the English language (both written and spoken): CAMBRIDGE ≥ FCE grade B (or equivalent).
  • Good communication skills and the ability to work as a part of a team and independently.

Monthly salary:

The successful candidates will receive an attractive salary in accordance with the MSCA regulations for Doctoral Researchers for a 3-year contract (full time employment). The salary includes a living allowance (gross amount: €3 311,60 per month), plus a mobility allowance (€600 per month), and a family allowance (€650 per month if applicable). The precise (net) salary will be confirmed upon appointment.

In addition, such a monthly salary, all REBONE fellows will benefit from a wide range of training and mentoring activities, which includes secondments to be organised at the premises of the REBONE Beneficiaries and Associated Partners, as well as of a wide variety of training modules (related to both scientific and transferable skills).

Where to request additional information for this position:

Prof. Pasquale Vena, email:

In order to complete the application procedure please prepare in advance the following documents:

  • Application summary and Privacy consent (pdf file, please download the form HERE)
  • CV using the European template (pdf file)
  • List of publications (pdf file, free format)
  • Copy of up to three selected publications, if available (zip file with three selected publications)
  • Certificate of English language (pdf file)
  • Signed copy of Identity card/Passport (pdf file)
  • Motivation letters (pdf file)
  • Two recommendation letters (zip file with two pdf)
  • A research proposal: A document with no more than 8000 characters (excluding Bibliography) describing a potential research activity pertinent to the specific topic of the DC to be recruited. Figures and tables are allowed. Template provided. (pdf file, please download the template HERE)